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GHRP 2-6 - growth hormone releasing peptides, acting on the pituitary gland, stimulate the release of growth hormone (somatotropin).
GHRP-2 - growth hormone stimulator[edit | edit code]
GHRP-2 Key application points GHRP-2
GHRP-2
(from the English.
Growth Hormone Releasing Peptide - 2
- peptide that releases growth hormone) or
Pralmorelin
- a stimulator of growth hormone (somatotropin), which has shown high effectiveness in people when administered sublingually and buccally. GHRP-2 is perhaps the only and most powerful booster (stimulator) of somatotropin production that currently exists. GHRP-2 is an oligopeptide that is able to penetrate through the vessels of the oral cavity and enter the bloodstream bypassing the liver. Studies have shown that GHRP-2 stimulates the pituitary gland, which leads to an increase in somatotropin secretion by 7-15 times (other growth hormone stimulants based on GABA and amino acids increase the level by no more than 2-3 times from the original).
Growth Hormone Releasing Peptide - 2 consists of six amino acids connected in series. This growth hormone stimulator is part of a group of peptides that interact with G protein-coupled receptors of the pituitary gland and hypothalamus; it also activates ghrelin receptors, which in turn leads to increased appetite.[1][2] These peptides were first obtained at the end of the last century from methenkephalin (an artificial peptide). Although GHRP-2 has no structural similarities to growth hormone-releasing hormone (an endogenous bioactive substance that naturally stimulates growth hormone production), it has demonstrated similar effects on the pituitary gland in clinical trials.
The growth hormone stimulator GHRP-2 has a low molecular weight, so it easily penetrates the well-vascularized oral mucosa, which avoids the parenteral route of administration. The effectiveness and good tolerability of the sublingual, intranasal and buccal administration of the drug is confirmed by medical studies.[3]
Clinical trial results published in the Journal of Endocrinology and Metabolism in 1997 showed that Growth Hormone Releasing Peptide - 2 increased growth hormone production in both children and adults, and even in the elderly.
Main effects[edit | edit code]
- Growth hormone secretion stimulator
- Increased appetite (due to activation of ghrelin receptors)[4]
- Reducing fat mass and increasing muscle mass (that is, increasing definition) [5]
- Reducing cholesterol levels
- Strengthening Bones
- Improving skin properties (rejuvenation effect)
- Protective effect on the liver
- Anti-inflammatory effect
GHRPeptide-2 is the most powerful and at the same time safe stimulator of somatotropin secretion of all those currently existing on the sports nutrition market (its potency can be compared with growth hormone preparations), which is confirmed by a number of independent studies, a key list of which is presented here.
Doses and regimen[edit | edit code]
The level of somatotropin depending on the dose of GHRP-2 when administered intranasally.
Studies have determined that the growth hormone stimulator GHRP-2 has a dose-dependent effect, that is, the increase in the level of somatotropin directly depends on the dose of this substance taken, and regardless of gender, age and amount fat mass.[6] Later, another study was conducted on children [7] where the dependence of the concentration of growth hormone on the dose of GHRP-2 was clearly determined (see graphs).
To obtain an effect in bodybuilding, GHRP-2 is used in a dose of 1-2 mcg
per 1 kg of body weight, 2-3 times a day.
That is, the average single dose of the drug in bodybuilding varies between 100-200 mcg
. Most often, 2-3 injections are performed every day (15 minutes before meals, after training and before bed), 100-200 mcg intramuscularly.[8][9][10][11] There are reports of the use of the substance at a dose of 1000 mcg 2-3 times a day, without the development of adverse reactions.[12] However, we do not recommend increasing the dose, since the rate of increase in the effect of the peptide is significantly reduced at doses above 200 mcg, and at the same time the concentration of cortisol and prolactin may increase. Yuri Bombela recommends using Cabergoline (Dostinex) to reduce prolactin.[13]
It is advisable to combine this peptide with GRF(1-29) or CJC-1295 to achieve maximum (synergistic) effect, save money and solve the problem of desensitization.[14]. Combined courses are described in the relevant articles.
Presumably due to the short half-life of GHRP-2, there is no significant increase in blood IGF-1 concentrations despite a high but transient increase in growth hormone.[15][16] Therefore, it is recommended to combine this drug with other peptides with a long half-life (CJC-1295)
Preparation and storage of the solution
[17]
You should cool the bottle to room temperature, then add the required volume of water for injection (which should flow down the wall of the bottle) and stir with smooth rotating movements (do not shake) or let it stand in the refrigerator. The solution is quite stable. Moreover, stability in this case does not depend on the type of solvent (bacteriostatic water or water for injection). Shelf life in the refrigerator is approximately 30-35 days.
Use of GHRP-6
Since GHRP-6 is used to achieve the same effects as growth hormone, it should only be used if there is an economic benefit.
For example, there is no growth hormone preparation on the market, or the athlete wants to stimulate its synthesis instead of direct administration. Also, the GHRP secretion peptide can be used as an accelerator of fat burning processes, accelerating the growth of muscle fiber mass in combination with AAS, improving the quality of the skin and in the treatment of injuries.
It should be noted that GHRP-6 is not used on a regular basis. This should only be done when necessary. Some athletes still use the peptide for a long time, but in this case it is worth reducing the dosage of the drug to the minimum allowable.
Sports nutrition[edit | edit code]
Synergistic effect of GHRP-2 and arginine (maximum concentration)
Growth hormone stimulants based on GHRP-2:
- Hexaghen by MuscleMeds
- Hemotropin from Nutrabolics
- Hemogex from VPX
- Xomatropin from ASN
So far, only these brands are on the market, and not a single manufacturer indicates the dose of GHRP-2, although this is the main component of the supplements. This circumstance may suggest that they use very low dosages that are not capable of producing the desired effect.
There is also a drug called Xentropin
, in which the proportion of the active substance is also unknown.
Combination[edit | edit code]
It is recommended to combine GHRP-2 supplements with other growth hormone stimulants - arginine, GABA and glutamine, this allows for a synergistic effect and increases growth hormone levels to a much greater extent.[18] The combination of these supplements is safe for health.
Is it possible to buy ghrp 6 in a pharmacy or in tablets?
The ghrp 2 peptide cannot be purchased at a pharmacy, so it is not supplied to pharmacy chains. It can only be ordered online in specialized stores. Some of them offer the product in tablet form, but this form of release is highly questionable. For the peptide to have the desired effect, it must enter the body without passing through the liver. Or at one time you will need to drink 30 bottles of GHRP 6, which in monetary terms will be about 10,000 rubles. At the same time, sellers offer the product in tablets for no more than 1,000. Thus, ghrp 2 in tablet form is a myth.
Notes[edit | edit code]
- Blandine Laferrere, Cynthia Abraham, Colleen D. Russell. Growth Hormone Releasing Peptide -2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. February 2005; 90(2): 611–614.
- Argente J, Garcia-Segura LM, Pozo J & Chowen JA. Growth hormone-releasing peptides: clinical and basic aspects. Hormone Research 1996 46 155–159.
- Department of Pediatrics at the University of Arkansas for Medical Sciences, published in the Journal of Endocrinology and Metabolism in 1995, “All 15 children had a significant GH response to 15 pg/kg dose.
- Blandine Laferrère, Cynthia Abraham, Colleen D. Russell and Cyril Y. Bowers – Growth Hormone Releasing Peptide-2 (GHRP-2), Like Ghrelin, Increases Food Intake in Healthy Men – Obesity Research Center (BL, CA, CDR), St . Luke's Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, 1090 Amsterdam Avenue, New York, New York 10025; and Tulane University Health Sciences Center (CYB), New Orleans, Louisiana 70112
- Gonadal status and body mass index jointly determine growth hormone (GH)-releasing hormone/GH-releasing peptide synergy in healthy men. J Clin Endocrinol Metab. 2008 Mar;93(3):944-50. Epub 2007 Dec 11
- Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN. Drugs in R&D 2004 5 236–239
- C Pihoker, R Middleton, GA Reynolds, CY Bowers and TM Badger — Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature — Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA ( 2006)
- https://www.ironmagazineforums.com/research-chemicals/158586-ghrp-2-dosing.html
- https://www.uk-muscle.co.uk/muscle-research-peptides/101507-ghrp-2-what-dose.html
- https://buypeptides.org/ghrp-ipamorelin/dosage-instructions.html
- https://bodypeptides.com/ghrp-2.php
- https://www.professionalmuscle.com/forums/peptides-growth-factors/88141-boom-dosing-ghrp-2-a.html
- https://anabolicstore.com.ua/index.php/articles/pharmacology/medicines/item/331-peptides-other-side
- "Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing's syndrome"
- https://joe.endocrinology-journals.org/content/155/1/79.full.pdf
- https://jcem.endojournals.org/content/91/12/4792.full
- Recommendations from Yuri Bombela
- Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise - Am J Physiol Regulatory Integrative Comp Physiol 279:1467-1477, 2000.
Combination with other peptides and supplements
We have already said that it is possible to enhance the already excellent effect of a course of GHRP-6 through synergy, that is, combining the use of drugs. In fact, there are quite a large number of combinations suitable for this peptide. Let's look at the main ones:
CJC-1295 - according to leading experts and a number of top-level athletes, this choice of combination is “golden”. This is explained by the fact that this peptide hormone enhances the effect of GHRP-6 significantly. And this, in turn, guarantees you incredible growth hormone production and excellent results.
GHRP 2 and 6 – we have already mentioned this combination. Sources say: such a pair will double the effect of the course.
Arginine – this amino acid will increase the effect by 10-20%.
Insulin - nothing to say here. The effect is simply incredible - an increase in efficiency by 30-40%.
Also, the combination of the GHRP-6 course can be carried out in tandem with glutamine or GABA .
Such combinations exist. They are very different, but quite effective. All that remains is to choose the one that is most suitable specifically for the characteristics of your body. And the result definitely won’t take long to arrive.
