Author: Vasily Roldugin - coach and master of sports in powerlifting | more details >> Master of Sports of Russia in powerlifting (IPF). 20 years of training experience. Trained 4 masters of sports and 15 candidates for IPF master of sports. Trained 1st international master of sports and 3 AWPC masters of sports. Prepared 1st World record holder and 3 WPC masters of sports. Coaching experience 15 years.
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Important! The “Your Trainer” website does not sell or encourage the use of anabolic steroids and other potent substances. The information is provided so that those who decide to take them do so as competently as possible and with minimal risk to health.
The androgenic-anabolic steroid (AAS) nandrolone, synthesized in 1950, is still one of the most popular in strength sports today. There are quite a large number of nandrolone esters: propionate, phenylpropionate, laurate, undecanoate, hexyloxyphenylpropionate, decanoate. The most common of them are phenylpropionate and decanoate.
Today we will talk about nandrolone decanoate, presented in such preparations as: Deca-Durabolin (25, 50, 100 mg/ml.), Retabolil (25, 50 mg/ml.), Deca-Durabol (25, 50, 100 mg/ml. .) and many others.
Properties of the drug: general characteristics
Content
Deca-durabolin is a drug, a long-acting anabolic steroid. The main active ingredient contained in the drug is nandrolone.
The structure of all anabolic steroids has much in common with the structure of testosterone, that is, the male sex hormone. But artificial drugs, of a kind, have great privileges, because you can build muscle with their help much faster.
Drug-Deca-Durabolin
The main properties of Deca-Durabolin include:
- androgenic properties – accumulation of male hormone;
- gain in body weight and strength;
- stimulation of fluid accumulation in tissues, which swells muscles;
- preventing joint damage;
- inhibition of cortisol receptors, which further increases muscle size.
It is worth considering that this effect will be noticeable in the case of adequate protein and calorie intake.
The drug Deca Durabolin in bodybuilding and other sports
This drug is considered the most popular and used among athletes, especially bodybuilders and weightlifters. Its popularity can be attributed to the quick and noticeable results on the body of every bodybuilder. This procedure is also carried out by people whose work involves daily physical activity and people whose work schedule does not have free time.
This injectable steroid contains a significant amount of bound nitrogen, which is one of the main components of protein. Deca durabolin promotes the accumulation of large amounts of nitrogen in the human muscle cell, which leads to a positive nitrogen balance and, as a result, muscle growth.
This drug is considered the most popular among athletes.
Manufacturers claim that when using this drug, a rapid activation of the nitrogen balance occurs, and along with this, protein also begins to be rapidly produced. In order for muscles not to lose their protein, you need a constant supply of proteins and calories to the body. If an athlete does not adhere to these rules, he will achieve results for a very long time.
Effects of taking Deca Durabolin
Durabolin is actively used around the world due to its positive effects:
- proper nutrition and training, combined with systematic use of the drug, increases muscle mass by 10 kg in one course;
- noticeable strengthening of bones and ligaments (previously used in the treatment of osteoporosis);
- increased synovial fluid, which eliminates joint pain;
- helps improve the absorption of nutrients by the intestine.
It is important to familiarize yourself with the negative effects of the drug:
- increased frequency of headaches;
- exacerbation of rhinitis;
- increased back pain;
- increased blood pressure.
Also during the course, abdominal cramps, depression and nervousness may occur.
Durabolin is actively used to prevent muscles from losing their protein.
Release options
The drug “Deca-Durabolin” is available in 2 ml bottles, which is very practical. Firstly, the bottle will not be damaged in your hands and will not spill, and secondly, it opens easier than ampoules. This drug exists in the form of a solution for intramuscular administration.
The composition and dosage of this drug may vary depending on the country in which it was created and the manufacturer. Ampoule composition: 1 ml of oil solution contains 25 or 50 mg of nandrolone decanoate.
Deca-Durabolin is one of the most popular drugs on the sports market, so it is often counterfeited and passed off as original.
According to Russian legislation, anabolic steroids are considered illegal potent substances. You can purchase this drug in the Russian Federation only at a pharmacy and only with a doctor’s prescription. Otherwise, article No. 234 “Illegal trafficking of potent or toxic substances for sales purposes.”
Dosage methods
In order for protein to be produced in the required quantity, the athlete must set his own dosage per 1 kg of weight, which will be about 4 mg per week. If the dosage is less than the specified dose, you will hardly notice the result.
The same thing happens if you increase the dose. For greater and faster results, the drug can be combined with others similar to it. But it’s best not to take risks, but to consult a doctor or specialist.
Deca Durabolin strengthens bones and joints
Instructions for use of Deca Durabolin state that the most acceptable dose of use is:
- for men – 200-600 mg per week, over 600 and 1000 mg will not bring better results;
- for women – 25-50 mg per week, for 12 weeks;
- for beginners – no more than 200 mg.
Side effects
Adverse reactions most often develop when using large dosages of the drug.
The medicine may cause:
- iron deficiency anemia , progression of atherosclerosis , peripheral edema;
- painful sensations in the abdomen, vomiting and nausea, disturbances in the liver ( jaundice );
- violations of blood clotting processes, bleeding;
- leukemia-like syndrome;
- headaches, disturbances in normal breathing, darkening of stool, vomiting with blood and other signs of hepatonecrosis ;
- hepatic purpura;
- hepatocellular carcinoma , spermatogenesis ;
- pain in the right side, dark urine, discoloration of stool, yellowing of the skin and other symptoms of cholestatic hepatitis .
Women may also experience:
- amenorrhea or dysmenorrhea ;
- increased hair growth, clitoral growth, voice changes;
- hypercalcemia.
The nature of adverse reactions that occur in men depends on age.
In the prepubertal period, men may experience: penis growth, accelerated formation of secondary sexual characteristics, skin rashes, acne , priapism , acceleration or cessation of growth, skin hyperpigmentation.
In the postpubertal period, the following are observed: an increase in the frequency of the urge to urinate, gynecomastia , an increase in the sensitivity and density of the mammary glands.
Male patients develop prostate carcinoma or .
Positive aspects of taking nandrolone
Despite the fact that many doctors criticize and do not recognize drugs with anabolic properties, this steroid is one of the few that pharmacologists and specialists recommend for use.
It is worth noting that Deca Durabolin can accumulate water in the body, which is very noticeable on the body of pumped-up athletes. The body becomes voluminous, elastic and has a presentable appearance. In addition to all this, water accumulated in connective tissue can completely relieve athletes from joint pain.
Another advantage is that the deck strengthens bones and joints and also supports the athlete’s immunity. Deca-Durabolin also leads to increased liver secretion, which cannot be considered a minus.
Chemical structure
Nandrolone decanoate - classified as an anabolic (its androgenic activity is lower than that of testosterone and is very weakly expressed, even if large doses are used), in small quantities in the body of every person, nandrolone dissolved in oil with decanoate attached through the 17-beta hydroxyl group ester (19-nortestosterone) its half-life in the body is approximately 7 to 10 days (the full period of work is 15-16 days), chemical formula C10H20O2. Esterified steroids are not as polar as free steroids and are not absorbed as quickly from the injection site. When the ester enters the circulatory system, it is split off and free nandrolone is found in the blood. The goal of developing esterified steroids was to prolong the therapeutic effect after injection, making it possible to inject less frequently when compared with injections of free steroids. Decanoate ester promotes the slow release of nandrolone from the injection site over three weeks. In its structure, nandrolone is similar to testosterone, but without the carbon atom in the 19th position. Just like testosterone, nandrolone has relatively strong anabolic properties, but unlike testosterone, its effect on the body is not as androgenic. The bulk of nandrolone in the body is converted into the weaker dihydronandrolone.
Historical reference
Nandrolone decanoate was first described in 1960; it began to be used in medicine already in 1962. The release of this drug was started by the Organon company, which supplied it to the market under the brand name Deca-Durabolin. Based on the name, it is clear that the drug includes a variety of the previously popular nandrolone - durabolin (phenylpropionate) with an ester of ten carbon atoms. Thanks to Organon, nandrolone decanoate becomes one of the most famous steroids on the world market. It has been used to treat many diseases, particularly dystrophy, osteoporosis, breast cancer, wasting, severe trauma, anemia and stunted growth in children. Initially it was released in a concentration of 50 mg/ml, later versions with concentrations of 100 mg/ml and 200 mg/ml appeared. After 1975, the scope of use of the drug was slightly reduced, but not significantly. Deca-Durabolin from Organon is still widely used today. It should be said that nandrolone decanoate is produced by many companies under various brand names.
Side effects when taking the drug
If you take Deca Durabolin in large doses over a long period of time, the male gonads will produce less testosterone than they should, which can lead to decreased sexual function.
Side effects when taking the drug
Also, anabolic steroids have a detrimental effect on the cardiovascular system, namely cholesterol levels. Frequent vaccinations can lead to a decrease in “good” cholesterol and an increase in “bad” cholesterol. In the future, this may cause the appearance of atherosclerosis.
Not excluded:
- nausea;
- vomit;
- acne;
- jaundice.
Taking this substance often leads to androgenic side effects. The sebaceous glands may begin to work intensively, and acne and pimples may appear. The appearance of excess hair on your body is not excluded if you decide to use the drug.
Pharmacodynamics and pharmacokinetics
After penetration into the systemic bloodstream, the substance interacts with specific receptor proteins located on the surface of target organs. In this way, a complex connection between the receptor and Nandrolone is formed, and the substance can freely move into the hyaloplasm , breaking through the cell membrane. Next, the compound penetrates through the nuclear membrane directly into the cell nucleus diffusion regulatory genes .
The drug stimulates the processes of synthesis of deoxyribonucleic acid and ribonucleic acid , some other structural acids, enhances tissue respiration and oxidative phosphorylation in skeletal muscles. As a result of these processes, muscle mass increases and active burning of fat deposits occurs. Creatine phosphate and ATP accumulate in skeletal muscles , the growth of male genital organs is accelerated, and the formation of secondary sexual characteristics is stimulated.
The growth zones located in the bones become calcified and the skeleton stops growing. Also Nandrolone Decanoate ( Nandrolone Decanoate ) stimulates spermatogenesis , sebaceous and male reproductive glands. When using large dosages of the drug, suppression of Leydig cells of endogenous sex hormones decreases , since the pituitary gland ceases to produce luteinizing and follicle-stimulating hormone .
Within 3-7 days after injection of the substance, the anabolic effect of the drug appears. In the glandular and integumentary epithelium , bones and muscles, reparative processes are activated, the speed and completeness of absorption of amino acids from the small intestine increases. This effect is especially noticeable when eating foods rich in proteins . erythropoietin is stimulated and anabolic processes in the brain are activated. If iron supplements are prescribed in parallel, the antianemic effect of treatment is manifested.
K-dependent blood coagulation factors in the liver tissue is disrupted the lipid profile of the blood plasma changes. The drug also promotes the development of edema due to the processes of reabsorption of fluid and sodium in the kidneys.
After administering 100 mg of Nandrolone oil solution intramuscularly, the maximum concentration in the blood is observed after 7-12 days. When used orally, the bioavailability of the drug is about 2%, while injections provide 100% absorption. In the body, the substance is metabolized in the liver, forming 17-ketosteroids . The drug is excreted mainly in urine, the rest in feces. The half-life is about a week. The drug is completely eliminated from the body within 3 weeks.
Combining Deca with other steroids
There are several effective, according to athletes, ways to combine drugs with high quality:
- The first method includes nandrolone 200-300 mg per week and methandrostenolone 20-40 mg daily.
- It is also considered effective to combine, for example, nandrolone 100-300 mg per week with testosterone 500 mg per week. This combination is perfect for those who want to gain weight in a short time, for example, before important competitions.
- Goes well with medication and Winstrol.
This drug can be combined with others similar to it
Reception of Deca by women
If a woman’s goal is to gain weight, then the vaccine should be 50 mg per week, which can be used once a month or every month and a half.
With a minimum dose of the drug (200 mg), significant changes in a woman’s hormonal background will not occur. If an athlete uses this steroid in large quantities or more often than necessary, you may notice some changes in her body.
It could be:
- changing the timbre of the voice to a rougher one;
- heavy hair growth, etc.
Also, when an injection is administered into a woman’s body, an increase in hemoglobin can be observed. At the same time, the loss of calcium in bone tissue will be significantly reduced. If suddenly a girl experiences any severe side effects, the drug should be stopped immediately so as not to harm the body.
After the body has completely recovered and recovered, you can again take the drug, which has a shorter effect (this steroid is more gentle and is active in the body for about a few days).
Dosage and regimen
The highest results are observed when used per kg. weight 4 ml. drug per week. However, if the total dose is less than 200 mg. / week, then the result after taking it will be weakly expressed.
That is why the most optimal dosage is considered to be in the range of 200-400 mg.
To achieve faster results, many increase the dose to almost 1,500 mg. / week, however, the increased dosage already at the border of 600 mg / week stops giving results. Beginners should generally limit themselves to a dosage of 200 mg. and gradually increase to 400 mg. / week.
Due to the long half-life of 7-10 days, it is recommended to give 1 injection per week, but to maintain a high concentration of the drug in the blood, it is worth giving an injection every 4 days, as indicated in the table:
The above information is relevant if the course is taken on a “solo” basis, i.e. He is the only one and no one else. It is convenient to use alone due to the fact that the drug itself gradually begins to act.
The first results of taking it can already be seen towards the end of 2 weeks of use. Therefore, the drug is effective when used alone or in combination with testosterone propionate at the very beginning of the cycle.
Reviews about this type of drug
This miracle drug has not left any avid athlete indifferent. Deca durabolin has a huge number of positive reviews, which the drug receives more and more every year.
People who take this substance are completely satisfied, because the results they have achieved amaze many. Athletes claim that deca is a reliable and effective drug for gaining weight and increasing strength. Also, people who live in constant physical activity note that joint pain does not bother them, and their immunity is always normal.
Athletes and bodybuilders are very pleased with this drug and recommend it to all those who participate in various competitions and want to keep themselves in shape.
After reading deca-durabolin reviews on various forums, you will notice that experts and people who have tried this anabolic steroid say with confidence that this drug is different from many other similar drugs and is one of the best, highest quality and fastest.
Indications for use
Nandrolone Decanoate, reviews of which from doctors confirm the complete safety of the drug, has a wide range of applications.
It is prescribed in the following cases:
- complex forms of diabetes mellitus;
- various infectious pathologies that have developed into a chronic form;
- rehabilitation after severe injuries and surgery;
- severe decrease in muscle mass and tone;
- Werdnig-Hoffmann amyotrophy;
- metastases of a malignant tumor;
- maintaining the body during long-term use of medications containing heavy salts;
- muscular dystrophy occurring in acute form;
- disruption of the electrophysiological process;
- postmenopausal and senile osteoporosis;
- various kidney pathologies;
- fibrosis and myeloid aplasia of the bone marrow;
- myelosclerosis;
- deficiency of pituitary growth hormone;
- breast cancer in women.
Today, a course of steroids (“Nandrolone Decanoate” or “Testosterone Enanthate” - one to choose from) is taken by professional athletes who constantly subject their bodies to grueling training. The drugs stimulate the growth of muscle tissue and increase physical capabilities. And the medicine also promotes the production of joint secretions, which strengthens ligaments and bones, thereby reducing the likelihood of injury.
